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Motoneuron Recruitment and Motor Evoked Potential Up-Conditioning (MEP) in Spinal Cord Injury (SCI)

Technology
General health
Online since 2 December 2025, updated 8 days ago
Curated trial

About this trial

This trial is enrolling 15 participants with chronic cervical spinal cord injury to test the effect of transcranial magnetic stimulation (TMS) on brain-to-muscle connections. TMS is s non-invasive technique which uses a magnetic field to stimulate the brain. A coil (held over the head) delivers the magnetic stimulation that activates the central nervous system. If included, participants will complete up to 42 sessions over 14 weeks, followed by 6 additional follow-up visits over 3 months, with each visit lasting about 1.5 hours. Final testing will be performed after 4 months.

Included participants

Gender
All
Age
≥ 18 years
Injury level
C1 - C6
  • Severity (AIS)?
    • Time since injury
    ≥ 12 months
    Healthy volunteers
    No
    C1-C6
    Additionally, participants must
    NOT have metal implants in the cranium
    NOT have implanted biomedical devices in or above the chest (e.g., a cardiac pacemaker, cochlear implant)

    What’s involved

    Type

    Technology

    Details

    - Participants will complete up to 42 sessions of transcranial magnetic stimulation (TMS) over 14 weeks, followed by 6 additional follow-up visits over 3 months, with each visit lasting about 1.5 hours. -TMS is s non-invasive technique which uses a magnetic field to stimulate the brain. A coil (held over the head) delivers the magnetic stimulation that activates the central nervous system. - Final testing will be performed after 4 months.

    Potential benefits

    Main benefits

    General health

    Additional benefits

    Arm/hand function

    Standing/walking/mobility

    Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more


    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 3 Nov 2025
    • Organisation
    • Medical University of South Carolina
    View on clinicaltrials.gov
    for more details
    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 3 Nov 2025
    • Organisation
    • Medical University of South Carolina
    View on clinicaltrials.gov
    for more details

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more

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