ARC-IM System to Manage Symptomatic Blood Pressure Instability Secondary to Chronic Spinal Cord Injury

Technology
General health
Online since 20 November 2025, updated 13 days ago

About this trial

This trial is enrolling 60 participants with chronic spinal cord injury to test the effect of epidural spinal stimulation on blood pressure. Epidural spinal stimulation is an invasive technique that uses an implanted electrode placed next to the spinal cord to deliver electrical stimulation aimed at modifying spinal cord function. If included, participants will undergo surgical implantation of the ARC-IM System and will be randomly assigned to undergo therapy sessions with either active or sham stimulation, followed by active stimulation for all participants after 3 months. Final testing of blood pressure stability will be performed after 6 months.

Included participants

Gender
All
Age
18 - 75 years
Injury level
C2 - T6
  • Severity (AIS)?
  • AIS-A
    AIS-B
    AIS-C
    AIS-D
    Time since injury
    ≥ 12 months
  • Injury type
  • Traumatic

    Healthy volunteers
    No
    C2-T6
    Additionally, participants must
    NOT have any active implanted medical device (e.g. baclofen pump, pacemaker).

    What’s involved

    Type

    Technology

    Details

    - Participants will undergo surgical implantation of the ARC-IM System, an epidural stimulator, and will be randomly assigned to undergo therapy sessions with either active or sham stimulation. - Epidural spinal stimulation (eSS) is an invasive technique that uses an implanted electrode placed next to the spinal cord to deliver electrical stimulation aimed at modifying spinal cord function. - After 3 months, all participants will receive active stimulation. - Final testing of blood pressure stability will be performed after 6 months.

    Potential benefits

    Main benefits

    General health

    Additional benefits

    Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more


    • Trial recruitment status
    • Recruiting soon
    • Trial start date
    • 1 Sep 2025
    • Organisation
    • ONWARD Medical, Inc.
    • Trial recruitment status
    • Recruiting soon
    • Trial start date
    • 1 Sep 2025
    • Organisation
    • ONWARD Medical, Inc.

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more