Combined Injury-site & Lumbosacral Epidural Spinal Cord Stimulation

Technology
Standing/walking/mobility
Online since 15 October 2025, updated 48 days ago

About this trial

This trial is enrolling 5 participants with chronic spinal cord injury to test the effect of epidural spinal stimulation ( eSS) on walking function. eSS is an invasive technique that uses an implanted electrode placed next to the spinal cord to deliver electrical stimulation aimed at modifying spinal cord function. If included, participants will undergo surgical implantation of a stimulator, followed by three sequential 3-month phases of stimulation (lumbosacral only, injury site only, and combined), alongside physiotherapy and exoskeleton training. Final testing of walking function will be performed after 1 year.

Included participants

Gender
All
Age
18 - 70 years
Injury level
C1 - S5
  • Severity (AIS)?
  • AIS-A
    AIS-B
    Time since injury
    ≥ 2 years
  • Injury type
  • Traumatic

    Non-traumatic

    Healthy volunteers
    No
    C1-S5

    What’s involved

    Type

    Technology

    Details

    - Participants will undergo surgical implantation of two stimulators, followed by three sequential 3-month phases of epidural spinal stimulation ( eSS) with stimulation at the lumbosacral level only, injury site only, and combined. - eSS is an invasive technique that uses implanted electrodes placed next to the spinal cord to deliver electrical stimulation aimed at modifying spinal cord function. - During all the phases, physiotherapy of individual muscle groups for walking will be arranged. Additionally, exoskeleton training will also be arranged for 4 to 5 hours per week. - Final testing of walking function will be performed after 1 year.

    Potential benefits

    Main benefits

    Standing/walking/mobility

    Additional benefits

    General health

    Mental health and psychosocial factors

    Pain

    Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more


    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 1 Sep 2025
    • Organisation
    • The University of Hong Kong
    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 1 Sep 2025
    • Organisation
    • The University of Hong Kong

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more