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Cuneiform Nucleus (CnF) Deep Brain Stimulation for Gait Facilitation Following Spinal Cord Injury

Technology
Standing/walking/mobility
Online since 18 November 2025, updated 15 days ago
Curated trial

About this trial

This trial is enrolling 6 participants with chronic incomplete spinal cord injury to test the effect of deep brain stimulation (DBS) on walking function. DBS is the stimulation of deeper parts of the brain through surgically implanted electrodes. In this study DBS targets an area of the brain called the cuneiform nucleus (CnF). If included, participants will undergo bilateral surgical implantation of DBS electrodes and participate in training sessions 3 times per week both before and after implantation. Final testing of walking function will be performed after 8 months.

Included participants

Gender
All
Age
22 - 70 years
Injury level
C1 - T10
  • Severity (AIS)?
    • AIS-C
    AIS-D
    Time since injury
    ≥ 12 months
    Healthy volunteers
    No
    C1-T10
    Additionally, participants must
    NOT have non-MRI compatible metallic implants in their head or body, and with metallic implants or other implantable devices in the body that could be affected by DBS

    What’s involved

    Type

    Technology

    Details

    - Participants will undergo bilateral surgical implantation of deep brain stimulation (DBS) electrodes. - DBS is the stimulation of deeper parts of the brain through surgically implanted electrodes. - Additionally, participants will attend 60-minute training sessions 3 times per week, before and after DBS implantation, including stretching, active hip mobility, weight shifting, stepping, and walking practice. - Final testing of walking function will be performed after 8 months.

    Potential benefits

    Main benefits

    Standing/walking/mobility

    Additional benefits

    General health

    Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more


    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 30 Nov 2025
    • Organisation
    • University of Miami
    View on clinicaltrials.gov
    for more details
    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 30 Nov 2025
    • Organisation
    • University of Miami
    View on clinicaltrials.gov
    for more details

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more

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