Epidural Electrical Stimulation in Spinal Cord Injury

Technology
General health
Online since 17 November 2025, updated 16 days ago

About this trial

This trial is enrolling 20 participants with thoracic spinal cord injury to test the effect of epidural spinal stimulation (eSS) on sensory and motor function. eSS is an invasive technique that uses an implanted electrode placed next to the spinal cord to deliver electrical stimulation aimed at modifying spinal cord function. If included, participants will be randomly assigned to either undergo surgical implantation of an eSS device and receive eSS combined with standard rehabilitation therapy, or receive standard rehabilitation only for 6 months. Final testing will be performed after 6 months.

Included participants

Gender
All
Age
18 - 60 years
Injury level
T1 - T10
  • Severity (AIS)?
  • AIS-B
    AIS-C
    AIS-D
    Time since injury
    4 months - 18 months
    Healthy volunteers
    No
    T1-T10
    Additionally, participants must
    NOT have implanted cardiac pacemakers, cardioverters, or defibrillators

    What’s involved

    Type

    Technology

    Details

    - Participants will be randomly assigned to either undergo surgical implantation of an epidural spinal stimulation (eSS) device and receive eSS combined with standard rehabilitation therapy or receive standard rehabilitation alone for 6 months. - eSS is an invasive technique that uses an implanted electrode placed next to the spinal cord to deliver electrical stimulation aimed at modifying spinal cord function. - Final testing will be performed after 6 months.

    Potential benefits

    Main benefits

    General health

    Additional benefits

    Arm/hand function

    Mental health and psychosocial factors

    Pain

    Sensory function

    Spasticity

    Standing/walking/mobility

    Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more


    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 1 Mar 2025
    • Organisation
    • Second Affiliated Hospital, School of Medicine, Zhejiang University
    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 1 Mar 2025
    • Organisation
    • Second Affiliated Hospital, School of Medicine, Zhejiang University

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more