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Effect of Threshold Pressure-Loaded RMT + tTBS on Respiratory Function in SCI Patients

Rehabilitation
General health
Online since 17 November 2025, updated 16 days ago
Curated trial

About this trial

This trial is enrolling 60 participants with acute spinal cord injury to test the effect of threshold pressure load respiratory muscle training (RMT), transcranial magnetic stimulation (TMS), and their combination on respiratory function. RMT is a technique that uses a small handheld device to create resistance while breathing in order to strengthen muscles. TMS is a non-invasive technique which uses a magnetic field to stimulate the brain. A coil (held over the head) delivers the magnetic stimulation that activates the central nervous system. If included, participants will be randomly assigned to one of three groups: (i) RMT; (ii) TMS; or (iii) a combination of both. Treatments will be given 5 days a week for 4 weeks. Final testing of respiratory function will be performed after 4 weeks.

Included participants

Gender
All
Age
18 - 80 years
Injury level
C1 - T12
  • Severity (AIS)?
    • AIS-A
    AIS-B
    AIS-C
    Time since injury
    2 weeks - 6 months
    Healthy volunteers
    No
    C1-T12
    Additionally, participants must
    NOT have any contradictions to magnetic stimulations (e.g. intracranial metal implants, pacemakers, etc.)
    NOT have severe cardiac or respiratory disease

    What’s involved

    Type

    Rehabilitation

    Details

    - Participants will be randomly assigned to one of three groups: (i) respiratory muscle training (RMT), (ii) transcranial magnetic stimulation (TMS), or (iii) a combination of both. - RMT is a technique that uses a small handheld device to create resistance while breathing and strengthen muscles. - TMS is a non-invasive technique which uses a magnetic field to stimulate the brain. A coil (held over the head) delivers the magnetic stimulation that activates the central nervous system circuits that produce movement of the diaphragm (the primary muscle for inhale). - Treatments will be given 5 days a week for 4 weeks. - Final testing of respiratory function will be performed after 4 weeks.

    Potential benefits

    Main benefits

    General health

    Additional benefits

    Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more


    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 25 Dec 2024
    • Organisation
    • Shengjing Hospital
    View on clinicaltrials.gov
    for more details
    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 25 Dec 2024
    • Organisation
    • Shengjing Hospital
    View on clinicaltrials.gov
    for more details

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more

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