Effect of Transauricular Vagal Stimulation on Cardiac Function After Spinal Cord Injury

Technology
General health
Online since 20 November 2025, updated 13 days ago

About this trial

This trial is enrolling 30 participants with chronic traumatic cervical spinal cord injury or lumbar spinal cord injury diagnosed with cauda equina syndrome) to test the effect of transauricular vagus nerve stimulation (VNS) on heart rate variability. VNS is a technique that uses mild electrical impulses on the skin (in this case on the ear) to stimulate the vagus nerve, a major nerve that helps regulate autonomic functions such as heart rate, digestion, and breathing. If included, participants will receive either active or sham VNS for 30 minutes a day on 10 consecutive days. Final testing of heart rate variability will be performed after 11 days.

Included participants

Gender
All
Age
18 - 60 years
Injury level
C1 - S5
  • Severity (AIS)?
  • Time since injury
    ≥ 6 months
  • Injury type
  • Traumatic

    Healthy volunteers
    No
    C1-S5
    Additionally, participants must
    NOT have a cardiac or neural pacemaker
    have history of autonomic dysreflexia
    cervical spinal cord injury

    What’s involved

    Type

    Technology

    Details

    - Participants will receive either active or sham transauricular vagus nerve stimulation (VNS) for 30 minutes per day on 10 consecutive days. - VNS is a technique that uses mild electrical impulses on the skin to stimulate the vagus nerve, a major nerve that helps regulate functions like heart rate, digestion, and breathing. - Final testing of heart rate variability will be performed after 11 days.

    Potential benefits

    Main benefits

    General health

    Additional benefits

    Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more


    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 20 Mar 2024
    • Organisation
    • Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 20 Mar 2024
    • Organisation
    • Gaziler Physical Medicine and Rehabilitation Education and Research Hospital

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more