Safety and Early Efficacy of iPSC-Derived Motor Neuron Progenitor Cells (XS228) in Subacute Spinal Cord Injury: A Phase I Trial
About this trial
This trial is enrolling 12 participants with acute spinal cord injury to test the safety and tolerability of a cell therapy (XS228) made from lab-grown nerve cells that may support and repair nerves. If included, participants will receive a single intraspinal injection of XS228 at one of two escalating dose levels (5×10⁷ or 1.5×10⁸ cells), followed by standard rehabilitation. Final testing of safety and tolerability will be performed after 1 year.
Included participants
Traumatic
Non-traumatic
What’s involved
Type
Details
- Participants will receive a single intraspinal injection of XS228 at one of two escalating dose levels (5×10⁷ or 1.5×10⁸ cells), followed by standard rehabilitation. - XS228 is a treatment made from lab-grown nerve cells that support and repair nerves. - Final testing of safety and tolerability will be performed after 1 year.
Potential benefits
Main benefits
General health
Additional benefits
Arm/hand function
Bladder health/function
Bowel health
Sensory function
Standing/walking/mobility
Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.
Wings for Life supports SCITrialsFinder
Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.
Learn more- Trial recruitment status
- Recruiting
- Trial start date
- 2 Jul 2025
- Organisation
- XellSmart Bio-Pharmaceutical (Suzhou) Co., Ltd.
- Trial recruitment status
- Recruiting
- Trial start date
- 2 Jul 2025
- Organisation
- XellSmart Bio-Pharmaceutical (Suzhou) Co., Ltd.
About this trial
Included participants
What’s involved
Potential benefits
Wings for Life supports SCITrialsFinder
Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.
Learn more