First-in-Human Clinical Trial of STUP-001, an In Vivo Direct Cell Conversion Gene Therapy for AIS-A/B Chronic Spinal Cord Injury
About this trial
This trial is enrolling 9 participants with chronic spinal cord injury to test the safety of STUP-001, a gene therapy that converts support cells in the spinal cord into nerve cells. If included, participants will be randomly assigned to receive a single administration of either 25 μL or 50 μL of STUP-001. Final testing of safety will be performed after 7 months.
Included participants
Traumatic
What’s involved
Type
Details
- Participants will be randomly assigned to receive a single intraoperative injection into the spinal cord of either 25 μL or 50 μL of STUP-001. - STUP-001 is a gene therapy that works to convert support cells in the spinal cord into nerve cells. - Final testing of safety will be performed after 7 months.
Potential benefits
Main benefits
General health
Additional benefits
Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.
Wings for Life supports SCITrialsFinder
Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.
Learn more- Trial recruitment status
- Recruiting
- Trial start date
- 30 Jul 2025
- Organisation
- Yonsei University
- Trial recruitment status
- Recruiting
- Trial start date
- 30 Jul 2025
- Organisation
- Yonsei University
About this trial
Included participants
What’s involved
Potential benefits
Wings for Life supports SCITrialsFinder
Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.
Learn more