Diet and Exercise Solutions to Postprandial Hypotension

Psychosocial/other
General health
Online since 4 September 2025, updated 90 days ago

About this trial

This trial is enrolling 13 participants with chronic spinal cord injury to test the effect of diets with high or low glycemic loads and post-meal lower-body electrical stimulation exercises on blood pressure. Glycemic load is a measure that estimates how much a food will raise a person’s blood glucose level after eating. Electrical stimulation is applied through the skin to activate nerves and induce contraction of weakened or paralyzed muscles. If included, participants will complete three study sessions in random order, receiving: (1) a high glycemic load meal (control group); (2) a low glycemic load meal; and (3) a high glycemic load meal followed by 1 hour of lower-body electrical stimulation exercises after eating. Final testing of blood pressure response will be performed after 3 days.

Included participants

Gender
All
Age
18 - 65 years
Injury level
C4 - T12
  • Severity (AIS)?
  • AIS-A
    AIS-B
    Time since injury
    ≥ 1 year
    Healthy volunteers
    No
    C4-T12
    Additionally, participants must
    NOT have type 1 or 2 diabetes
    NOT have an implanted pacemaker or defibrillator
    previous bariatric surgery

    What’s involved

    Type

    Psychosocial/other

    Details

    - Participants will complete three study sessions in random order, receiving: (1) a high glycemic load meal (control group), (2) a low glycemic load meal, and (3) a high glycemic load meal followed by 1 hour of lower-body electrical stimulation exercises after eating. - Glycemic load is a measure that estimates how much a food will raise a person’s blood glucose level after eating. - Electrical stimulation is applied through the skin to activate nerves and induce contraction of weakened or paralyzed muscles. - Final testing of blood pressure response will be performed after 3 days.

    Potential benefits

    Main benefits

    General health

    Additional benefits

    Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more


    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 15 May 2025
    • Organisation
    • Ohio State University
    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 15 May 2025
    • Organisation
    • Ohio State University

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more