Rehabilitation Combining Spatiotemporal Spinal Cord Stimulation and Real-time Triggering Exoskeleton After Spinal Cord Injury

Surgery
Standing/walking/mobility
Online since 4 September 2025, updated 62 days ago

About this trial

This trial is enrolling 10 participants with chronic spinal cord injury to examine the effect of epidural spinal stimulation (eSS) combined with robotic exoskeleton therapy on lower limb function. eSS is an invasive technique that uses an implanted electrode array placed next to the spinal cord to deliver electrical stimulation aimed at modifying spinal cord function. An exoskeleton is an externally worn powered robotic device to assist movement. If included, participants will undergo implantation of an eSS system, followed by daily exoskeleton-assisted gait training alongside standard therapy. Final testing of lower limb function will be performed after 1 year.

Included participants

Gender
All
Age
14 - 65 years
Injury level
C1 - S5
  • Severity (AIS)?
  • AIS-A
    AIS-B
    AIS-C
    Time since injury
    ≥ 6 months
    Healthy volunteers
    No
    C1-S5
    Additionally, participants must
    NOT have active implanted devices, such as a pacemaker, defibrillator, drug infusion pump, cochlear implant, sacral nerve stimulator, etc.

    What’s involved

    Type

    Surgery

    Details

    - Participants will undergo implantation of an epidural spinal stimulation (eSS) system, followed by daily exoskeleton-assisted gait training alongside standard therapy. - eSS is an invasive technique that uses an implanted electrode placed next to the spinal cord to deliver electrical stimulation aimed at modifying spinal cord function. - An exoskeleton is an externally worn powered robotic device to assist movement. - Exoskeleton-assisted gait training sessions will last no less than 1 hour per day, divided into two 30-minute sessions. Other rehabilitation interventions will be provided for at least 3 hours per day. - Final testing of lower limb function will be performed after 1 year.

    Potential benefits

    Main benefits

    Standing/walking/mobility

    Additional benefits

    Arm/hand function

    Bladder health/function

    Bowel health

    General health

    Mental health and psychosocial factors

    Pain

    Sensory function

    Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more


    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 13 Oct 2024
    • Organisation
    • Xuanwu Hospital, Beijing
    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 13 Oct 2024
    • Organisation
    • Xuanwu Hospital, Beijing

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more