Spinal Cord Injury Neurorecovery Collaboration

About this trial

This trial is enrolling 24 participants with chronic, incomplete cervical spinal cord injury to test the effect of therapeutic intermittent hypoxia combined with upper limb and respiratory exercise training. Intermittent hypoxia is an intervention to potentially promote nerve plasticity and motor recovery resulting from repeatedly breathing air with low oxygen content for brief periods, alternating with breathing room air with normal oxygen content. If included, participants will follow a predominantly home-based intervention protocol involving therapeutic intermittent hypoxia and targeted exercise training 3 times per week for 6 weeks. Final testing of respiratory and upper limb function will be performed after 6 weeks.