Clinical Testing of Invasive Spinal Cord Stimulation and Evaluation of Its Physiological Effects Using the Electroencephalography

Surgery
General health
Online since 4 September 2025, updated 7 days ago

About this trial

This trial is enrolling 35 participants with spinal cord injury to test the effect of epidural spinal stimulation (eSS) on brain activity. eSS is an invasive technique that uses an implanted electrode placed next to the spinal cord to deliver electrical stimulation aimed at modifying spinal cord function. If included, participants will undergo surgical implantation of an epidural spinal stimulator, followed by an individualized eSS program. Final testing of brain activity will be performed after 2 weeks.

Included participants

Gender
All
Age
All ages
Injury level
C1 - S5
  • Severity (AIS)?
  • Time since injury
    All
    Healthy volunteers
    No
    C1-S5
    Additionally, participants must
    NOT have a history of epilepsy, stroke, or cancer

    What’s involved

    Type

    Surgery

    Details

    - Participants will undergo surgical implantation of an epidural spinal stimulator, followed by an individualized program of epidural spinal stimulation (eSS). - eSS is an invasive technique that uses an implanted electrode placed next to the spinal cord to deliver electrical stimulation aimed at modifying spinal cord function. - Final testing of brain activity will be performed after 2 weeks.

    Potential benefits

    Main benefits

    General health

    Additional benefits

    Arm/hand function

    Bladder health/function

    Bowel health

    Mental health and psychosocial factors

    Pain

    Sensory function

    Standing/walking/mobility

    Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more


    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 22 Apr 2023
    • Organisation
    • Far Eastern Federal University
    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 22 Apr 2023
    • Organisation
    • Far Eastern Federal University

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more