Treating Central Neuropathic Pain With Low Dose Naltrexone for People With Spinal Cord Injury

Drug
Mental health and psychosocial factors
Online since 15 October 2025, updated 48 days ago

About this trial

This pilot trial is enrolling 10 participants with chronic spinal cord injury to test the effect of low-dose naltrexone on pain. Naltrexone is a medication that can help regulate the nervous system. If included, participants will take an oral dose of 4.5 mg of naltrexone daily for 12 weeks. Final assessment of pain will be performed after 12 weeks.

Included participants

Gender
All
Age
≥ 18 years
Injury level
C1 - T12
  • Severity (AIS)?
  • Time since injury
    ≥ 6 months
  • Injury type
  • Traumatic

    Healthy volunteers
    No
    C1-T12
    Additionally, participants must
    experience central neuropathic pain, based on evaluation by a Physical medicine and rehabilitation physician

    What’s involved

    Type

    Drug

    Details

    - Participants will take an oral dose of 4.5 mg of naltrexone daily for 12 weeks. - Naltrexone is a medication that can help regulate the nervous system. - Final assessment of pain will be performed after 12 weeks.

    Potential benefits

    Main benefits

    Mental health and psychosocial factors

    Additional benefits

    General health

    Pain

    Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more


    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 1 Feb 2025
    • Organisation
    • Medical College of Wisconsin
    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 1 Feb 2025
    • Organisation
    • Medical College of Wisconsin

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more