Improving Pelvic Rehabilitation Using Epidural Stimulation After Spinal Cord Injury

Technology
Bladder health/function
Online since 17 January 2025, updated 291 days ago

About this trial

This trial is enrolling 20 individuals with chronic spinal cord injury above the sacral area and who have overactive bladder function to test the effect of epidural spinal cord stimulation (eSCS) combined with pelvic floor muscle training (PFMT) on bladder function. eSCS is a technique for stimulating the spinal cord with implanted electrodes placed next to the spinal cord to modify spinal cord function. If included, participants will undergo implantation of eSCS electrodes (Phase I) and will use eSCS at home for 12 weeks combined with PFMT (Phase II). Final testing of bladder function will be performed after 40 weeks.

Included participants

Gender
All
Age
≥ 18 years
Injury level
C1 - L5
  • Severity (AIS)?
  • AIS-A
    AIS-B
    AIS-C
    AIS-D
    Time since injury
    ≥ 1 year
    Healthy volunteers
    No
    C1-L5
    Additionally, participants must
    have neurogenic detrusor overactivity.
    Not have history of bladder sphincter surgery

    What’s involved

    Type

    Technology

    Details

    - Participants will undergo implantation of epidural spinal cord stimulation (eSCS) electrodes and will use eSCS at home for 12 weeks alongside pelvic floor muscle training (PFMT). - eSCS is a technique for stimulating the spinal cord with an implanted electrode placed next to the spinal cord to modify spinal cord function. - Final testing of bladder function will be performed after 40 weeks.

    Potential benefits

    Main benefits

    Bladder health/function

    Additional benefits

    Arm/hand function

    Bowel health

    General health

    Mental health and psychosocial factors

    Sensory function

    Sexual health

    Standing/walking/mobility

    Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more


    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 14 Oct 2024
    • Organisation
    • University College, London
    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 14 Oct 2024
    • Organisation
    • University College, London

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more