A Novel Repetitive Synchronized Associative Stimulation Neuromodulation Approach for Spinal Cord Injury Patients

About this trial

This trial is enrolling 25 individuals with spinal cord injury to test the effect of different stimulation methods on specific muscle groups. If included, participants will undergo either: i) transcranial magnetic stimulation (TMS) to activate the brain; ii) electrical spinal cord stimulation (SCS) to activate the spinal cord; iii) functional electrical stimulation (FES) to activate arms, legs) and trunk; or iv) sham TMS. TMS is a non-invasive technique which uses a magnetic field to stimulate the brain. A coil (held over the head) delivers the magnetic stimulation to activate the central nervous system. SCS is a technique for stimulating the spinal cord via surface electrodes to modify spinal cord function. FES is a technique that applies electrical stimulation through the skin to nerves to cause contraction of weakened or paralyzed muscles. Final testing of muscle activation and response will be performed after 2 months.