Efficacy of rTMS Treatment After Spinal Cord Injury

Technology
Standing/walking/mobility
Online since 3 July 2024, updated 12 days ago

About this trial

There is accumulating evidence that neuromodulation by repetitive transcranial magnetic stimulation (rTMS) of the motor cortex holds promise as a treatment for rehabilitation of motor function followi...

Included participants

Gender
All
Age
18 - 80 years
Injury level
C4 - T12
  • Severity (AIS)?
  • AIS-C
    AIS-D
    Time since injury
    All
  • Injury type
  • Traumatic

    Non-traumatic

    Healthy volunteers
    Yes
    C4-T12
    Additionally, participants must
    NOT have implanted devices such as cardiac pacemaker and neurostimulator and cochlear implants
    NOT have an active cerebral tumor
    NOT have a history of epilepsy or ongoing epilepsy

    What’s involved

    Type

    Technology

    Details

    The investigators will recruit 20 patients with low cervical or thoracic ASIA C or D spinal cord injuries based on specific inclusion and exclusion criteria. The patients will be randomized into 2 groups. Each group will receive either the theta burst stimulation or the placebo stimulation. rTMS will be delivered using a figure-of-eight coil positioned on the patient's head, targeting the leg area of the primary motor cortex. After the motor threshold (MT) is determined patients will receive a unilateral 90% subthreshold theta burst stimulation for 3 minutes The protocol includes 15 stimulation sessions over a 3-week period. The 12-week follow up consist of a series of electrophysiological and functional tests to assess upper and lower limb function bilaterally. Secondary outcomes include pain using the NRS scale, and self-reported evaluation of autonomic functions before, during, and after the treatment.

    Potential benefits

    Main benefits

    Standing/walking/mobility

    Additional benefits

    Arm/hand function

    General health

    Pain

    Spasticity

    Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more

    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 15 Jan 2024
    • Organisation
    • Oslo University Hospital
    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 15 Jan 2024
    • Organisation
    • Oslo University Hospital

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more