Brain-Controlled Spinal Stimulation Walking Therapy After Incomplete Spinal Cord Injury (SCI)

Technology

Standing/walking/mobility

Online since 7 October 2024, updated 74 days ago

About this trial

This trial is enrolling 10 participants with chronic incomplete spinal cord injury to test the effect of Brain-Computer Interface (BCI)-Transcutaneous Spinal Cord Stimulation (TSCS) on walking function. BCI is a technique using a computer and non-invasive connected electrodes on the scalp to record brain activity and also to control an external device. TSCS is a technique for stimulating the spinal cord via surface stimulation to modify spinal cord function. If included, participants will undergo BCI-TSCS therapy 3-4 times per week, which includes activity-based training for up to 6 months. The TSCS is activated by a BCI system that detects movement attempts. Final testing of walking function will be performed after 6 months.

Included participants

Gender

All

Age

21 - 70 years

Injury level

C1 - T10

Severity (AIS)?

AIS-B

AIS-C

AIS-D

Time since injury

≥ 6 months

Healthy volunteers

C1-T10

Additionally, participants must

NOT have traumatic brain injury, stroke, multiple sclerosis, or other neuromuscular disorders that could affect neuromotor function and walking.

NOT have metal implants in their head

walk overground for at least 10 meters with some assistance of a therapist and minimal body-weight support

What’s involved

Type

Technology

Details

- Participants will undergo Brain-Computer Interface (BCI)-Transcutaneous Spinal Cord Stimulation (TSCS) therapy 3-4 times per week, which includes activity-based training. - BCI is a technique using a computer and connected electrodes on the scalp to record brain activity and also to control an external device. - TSCS is a technique for stimulating the spinal cord via surface stimulation to modify spinal cord function. - During the therapy sessions, the TSCS is activated by a BCI system that detects movement attempts. - Final testing of walking function will be performed after 6 months.

Potential benefits

Main benefits

Standing/walking/mobility

Additional benefits

Arm/hand function

General health

Mental health and psychosocial factors

Spasticity

Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

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