Restoration of Bladder Function in Spinal Cord Injury

Technology
Bladder health
Online since 20 October 2023, updated 122 days ago

About this trial

This trial is enrolling 5-10 individuals with chronic complete spinal cord injuries who have undergone implantation of a Sacral Anterior Root Stimulator (SARS), Finetech Brindley Bladder stimulator, to test the effect of high frequency stimulation on bladder function. SARS is a technique for stimulating nerves that exit at the lowest part of the spinal cord with implanted electrodes. The study will explore new stimulation parameters using a modified external stimulation control unit. If included, participants will receive SARS with high frequency (up to 600Hz), compared with the effect of usual low frequency.

Included participants

Gender
All
Age
≥ 18 years
Injury level
C1 - S5
  • Severity (AIS)?
  • AIS-A
    AIS-B
    Time since injury
    All
    Healthy volunteers
    No
    C1-S5
    Additionally, participants must
    have undergone implantation of a Finetech Brindley Bladder controller, with or without sacral posterior rhizotomy
    NOT have undergone external urethral sphincterotomy

    What’s involved

    Type

    Technology

    Details

    - Participants will receive high and low frequency stimuli applied to sacral afferent nerves with the already implanted Finetech Brindley bladder stimulator. - Outcome measures will be compared with different frequencies of electrical stimuli and with no electrical stimuli.

    Potential benefits

    Main benefits

    Bladder health

    Additional benefits

    General health

    Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more

    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 18 Nov 2021
    • Organisation
    • University of Oxford
    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 18 Nov 2021
    • Organisation
    • University of Oxford

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more