SVF Combined With Functional Self-assembling Peptide Nanofiber Hydrogels in the Treatment of Spinal Cord Injury

Biological/cell based
Standing/walking/mobility
Online since 18 October 2023, updated 173 days ago

About this trial

This trial is enrolling 15 individuals with chronic complete thoracic spinal cord injuries to test the effect of a cell therapy called Stromal Vascular Fraction (SVF) combined with a structural support by way of functional self-assembling peptide nanofiber hydrogels. If included, participants will undergo surgery with implantation of SVF and hydrogel material. Final testing for walking and other functions will be performed after 12 months.

Included participants

Gender
All
Age
18 - 60 years
Injury level
T1 - T12
  • Severity (AIS)?
  • AIS-A
    Time since injury
    ≥ 3 months
  • Injury type
  • Traumatic

    Healthy volunteers
    No
    T1-T12
    Additionally, participants must
    NOT have osteoporosis or had joint disease
    NOT have internal medical and/or infectious diseases
    have rating A on the American Spinal Injury Association (ASIA) measurement scale

    What’s involved

    Type

    Biological/cell based

    Details

    - Participants will undergo spinal surgery that includes implantation of Stromal Vascular Fraction (SVF) and functional self-assembling peptide nanofiber hydrogels at the site of injury. - SVF is a heterogeneous mixture of cells obtained from adipose (fat) tissue. - Hydrogels can support 3D stem cell growth and may promote neural regeneration. - Final testing will be performed after 12 months.

    Potential benefits

    Main benefits

    Standing/walking/mobility

    Additional benefits

    Sexual health

    Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more

    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 15 Jul 2023
    • Organisation
    • Kunming Tongren Hospital
    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 15 Jul 2023
    • Organisation
    • Kunming Tongren Hospital

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more