SVF Combined With Functional Self-assembling Peptide Nanofiber Hydrogels in the Treatment of Spinal Cord Injury

Biological/cell based

Standing/walking/mobility

Online since 18 October 2023, updated 568 days ago

About this trial

This trial is enrolling 15 individuals with chronic complete thoracic spinal cord injuries to test the effect of a cell therapy called Stromal Vascular Fraction (SVF) combined with a structural support by way of functional self-assembling peptide nanofiber hydrogels. If included, participants will undergo surgery with implantation of SVF and hydrogel material. Final testing for walking and other functions will be performed after 12 months.

Included participants

Gender

All

Age

18 - 60 years

Injury level

T1 - T12

Severity (AIS)?

AIS-A

Time since injury

≥ 3 months

Injury type

Traumatic

Healthy volunteers

T1-T12

Additionally, participants must

NOT have osteoporosis or had joint disease

NOT have internal medical and/or infectious diseases

have rating A on the American Spinal Injury Association (ASIA) measurement scale

What’s involved

Type

Biological/cell based

Details

- Participants will undergo spinal surgery that includes implantation of Stromal Vascular Fraction (SVF) and functional self-assembling peptide nanofiber hydrogels at the site of injury. - SVF is a heterogeneous mixture of cells obtained from adipose (fat) tissue. - Hydrogels can support 3D stem cell growth and may promote neural regeneration. - Final testing will be performed after 12 months.

Potential benefits

Main benefits

Standing/walking/mobility

Additional benefits

Sexual health

Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

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Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

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