NVG-291 in Spinal Cord Injury Subjects

Drug
Standing/walking/mobility
Online since 7 December 2023, updated 162 days ago

About this trial

This trial is enrolling 40 individuals with chronic (1-10 years) and subacute (10-49 days) cervical spinal cord injury to test the safety and effect of an experimental drug, NVG-291. If included, participants will receive a daily subcutaneous (under the skin) injection for 12 weeks of either: 1) NVG-291; or 2) a placebo drug. In lab studies, NVG-291 improved locomotion and bladder recovery. Final testing of central nervous system conduction (electrophysiology) as well as upper and lower limb function will be assessed after 16 weeks.

Included participants

Gender
All
Age
18 - 75 years
Injury level
C1 - C7
  • Severity (AIS)?
  • AIS-B
    AIS-C
    AIS-D
    Time since injury
    10 days - 10 years
  • Injury type
  • Traumatic

    Healthy volunteers
    No
    C1-C7
    Additionally, participants must
    NOT have a spinal cord injury due to gunshot wound or penetrating injury
    NOT have an implanted device in the brain or spinal cord
    NOT have an implanted pacemaker

    What’s involved

    Type

    Drug

    Details

    - participants will receive either a single injection of 1) NVG-291 or 2) a placebo drug, under the skin. - Final testing of upper and lower limb function will be assessed after 16 weeks.

    Potential benefits

    Main benefits

    Standing/walking/mobility

    Additional benefits

    Arm/hand function

    General health

    Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more

    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 8 Aug 2023
    • Organisation
    • NervGen Pharma
    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 8 Aug 2023
    • Organisation
    • NervGen Pharma

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more