Treatment of Orthostatic Hypotension in SCI

About this trial

This trial is enrolling 25 individuals with chronic cervical/thoracic spinal cord injury for 2 studies on blood pressure. Study 1 will test the effect of midodrine and droxidopa on blood pressure in seated or supine positions. Study 2 compares the use of a compression garment, midodrine, and droxidopa against placebo on blood pressure and other symptoms of blood pressure changes. If included, participants will visit the laboratory on 6 occasions to receive increasing doses of midodrine or droxidopa (study 1). For study 2, the use of compression garments, midropine, or droxidopa will be compared to placebo to assess the effect on blood pressure control, autonomic dysreflexia, orthostatic hypotension, fatigue and thermal comfort. Final assessments will be performed after 3 years.