SCED Myokines and Cognition in SCI

Technology
General health
Online since 11 September 2023, updated 162 days ago

About this trial

This trial is enrolling 15 individuals with chronic spinal cord injuries to test the effect of neuromuscular electrical stimulation (NMES) on cognitive function. If included, participants will undergo a 12 week NMES program, three times a week. NMES consists of electrical stimulation applied for 30 min to the front thigh muscles of both legs. Investigators want to see if the stimulation improves cognitive test scores by changing blood levels of BDNF, a nerve growth and survival protein (myokine). Final testing of cognitive function will be performed 12 weeks after the intervention.

Included participants

Gender
All
Age
≥ 18 years
Injury level
C1 - L2
  • Severity (AIS)?
  • AIS-A
    AIS-B
    AIS-C
    Time since injury
    ≥ 1 year
    Healthy volunteers
    No
    C1-L2

    What’s involved

    Type

    Technology

    Details

    - Participants will undergo a 12 week NMES program, three times a week. - NMES: 30 min electrical stimulation applied to the front thigh muscles of both legs. - Final testing of cognitive function will be performed 12 weeks after the intervention.

    Potential benefits

    Main benefits

    General health

    Additional benefits

    Mental health

    Pain

    Spasticity

    Standing/walking/mobility

    Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more

    • Trial recruitment status
    • Recruiting soon
    • Trial start date
    • 1 Jan 2024
    • Organisation
    • Adelante, Centre of Expertise in Rehabilitation and Audiology
    • Trial recruitment status
    • Recruiting soon
    • Trial start date
    • 1 Jan 2024
    • Organisation
    • Adelante, Centre of Expertise in Rehabilitation and Audiology

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more