SCED Myokines and Cognition in SCI

Technology

General health

Online since 11 September 2023, updated 310 days ago

About this trial

This trial is enrolling 15 individuals with chronic spinal cord injuries to test the effect of neuromuscular electrical stimulation (NMES) on cognitive function. If included, participants will undergo a 12 week NMES program, three times a week. NMES consists of electrical stimulation applied for 30 min to the front thigh muscles of both legs. Investigators want to see if the stimulation improves cognitive test scores by changing blood levels of BDNF, a nerve growth and survival protein (myokine). Final testing of cognitive function will be performed 12 weeks after the intervention.

Included participants

Gender

All

Age

≥ 18 years

Injury level

C1 - L2

Severity (AIS)?

AIS-A

AIS-B

AIS-C

Time since injury

≥ 1 year

Healthy volunteers

C1-L2

What’s involved

Type

Technology

Details

- Participants will undergo a 12 week NMES program, three times a week. - NMES: 30 min electrical stimulation applied to the front thigh muscles of both legs. - Final testing of cognitive function will be performed 12 weeks after the intervention.

Potential benefits

Main benefits

General health

Additional benefits

Mental health and psychosocial factors

Pain

Spasticity

Standing/walking/mobility

Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

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