Epidural Stimulation in Chronic Spinal Cord Injury Patients

Technology
Standing/walking/mobility
Online since 16 August 2023, updated 187 days ago

About this trial

This trial is enrolling 5 individuals with chronic spinal cord injuries between C7 and T10 to test the effect of epidural stimulation (ES) on autonomic and leg function. ES is a technique for stimulating the spinal cord with a surgically implanted electrode placed next to the spinal cord. If included, participants will receive 80 sessions of ES. Brain imaging will be performed with magnetic resonance imaging before and after the intervention. Investigators will measure leg function as well as changes in trunk stability, bowel and bladder function, spasticity, pain, blood pressure, sexual function, and quality of life. Final testing will be performed after 1 year.

Included participants

Gender
All
Age
18 - 60 years
Injury level
C7 - T10
  • Severity (AIS)?
  • AIS-A
    AIS-B
    Time since injury
    ≥ 2 years
    Healthy volunteers
    No
    C7-T10
    Additionally, participants must
    NOT be currently ventilator dependent

    What’s involved

    Type

    Technology

    Details

    - participants will receive 80 sessions of ES. - Brain imaging will also be performed using non-invasive magnetic resonance imaging before and after the intervention. - Final testing of autonomic and leg function will be performed after 1 year.

    Potential benefits

    Main benefits

    Standing/walking/mobility

    Additional benefits

    Bladder health

    Bowel health

    General health

    Mental health

    Pain

    Sexual health

    Spasticity

    Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more

    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 1 Jan 2023
    • Organisation
    • University Hospital, Motol
    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 1 Jan 2023
    • Organisation
    • University Hospital, Motol

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more