Impact of Peripheral Afferent Input on Central Neuropathic Pain

Drug
Pain
Online since 23 August 2023, updated 229 days ago

About this trial

This trial is enrolling individuals with spinal cord injuries to test the effect of a drug (Lidocaine injection) on chronic pain. Lidocaine is a local anesthetic that blocks the electrical signals in nerves. If included, participants will receive injections close to nerves in the arm or leg of either: 1) a Lidocaine (10 mg/ml) injection; or 2) a placebo injection using isotonic saline. Final pain testing will be performed after 95 minutes.

Included participants

Gender
All
Age
18 - 80 years
Injury level
C1 - T12
  • Severity (AIS)?
  • AIS-A
    AIS-B
    AIS-C
    AIS-D
    Time since injury
    ≥ 1 year
  • Injury type
  • Traumatic

    Non-traumatic

    Ischemia

    Spinal cord stroke

    Healthy volunteers
    No
    C1-T12

    What’s involved

    Type

    Drug

    Details

    - 1) Lidocaine (10 mg/ml) injection or 2) a placebo injection using isotonic saline targeting peripheral nerves in arms or legs related to chronic pain sensations. Final pain testing will be performed after 95 minutes.

    Potential benefits

    Main benefits

    Pain

    Additional benefits

    General health

    Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more

    • Trial recruitment status
    • Recruiting soon
    • Trial start date
    • 1 Dec 2022
    • Organisation
    • University of Aarhus
    • Trial recruitment status
    • Recruiting soon
    • Trial start date
    • 1 Dec 2022
    • Organisation
    • University of Aarhus

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more