Brivaracetam to Reduce Neuropathic Pain in Chronic SCI: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Drug
Pain
Online since 16 August 2023, updated 35 days ago

About this trial

This trial is enrolling individuals with traumatic spinal cord injuries (at least 3 months since injury) to test the effect of a drug (brivaracetam) on neuropathic pain. If included, participants will receive either: 1) 50mg brivaracetam twice a day for 2 weeks, followed by 50mg three times a day for 2 weeks, followed by 100mg twice a day for 48 days, as tolerated; or 2) placebo drug. Final pain testing will be performed after 3 months.

Included participants

Gender
All
Age
≥ 18 years
Injury level
C1 - S5
  • Severity (AIS)?
  • Time since injury
    ≥ 3 months
  • Injury type
  • Traumatic

    Healthy volunteers
    No
    C1-S5
    Additionally, participants must
    have completed inpatient rehab

    What’s involved

    Type

    Drug

    Details

    - Participants will receive either 1) 50mg brivaracetam twice a day for 2 weeks, followed by 50mg three times a day for 2 weeks, followed by 100mg twice a day for 48 days, as tolerated or 2) placebo drug.- - Final pain testing will be performed after 3 months.

    Potential benefits

    Main benefits

    Pain

    Additional benefits

    General health

    Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more

    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 1 Jan 2023
    • Organisation
    • University of Minnesota
    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 1 Jan 2023
    • Organisation
    • University of Minnesota

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more