Effects of Cannabidiol (CBD) on Resting-state Electroencephalography (EEG) and Neuropathic Pain Severity in People With Spinal Cord Injury (SCI)

Drug
Pain
Online since 28 August 2023, updated 181 days ago

About this trial

This trial is enrolling individuals with spinal cord injuries to test the effect of Cannabidiol (CBD) on pain severity. If included, participants will receive either: 1) CBD on day one followed by placebo within a two week follow-up period; or 2) placebo first followed by CBD. Researchers will measure the effect of CBD on pain symptoms, pain intensity, pain unpleasantness, and skin sensitivity to hot and cold temperature; they will also measure the effect of CBD on brain electrical activity using electroencephalography (EEG). Final testing will be performed 3 hours after each intervention.

Included participants

Gender
All
Age
18 - 64 years
Injury level
C1 - S5
  • Severity (AIS)?
  • AIS-A
    AIS-B
    AIS-C
    AIS-D
    Time since injury
    All
  • Injury type
  • Traumatic

    Healthy volunteers
    No
    C1-S5
    Additionally, participants must
    NOT have psychopathology
    NOT have presence of significant medical illness
    have had continuous neuropathic pain for three months

    What’s involved

    Type

    Drug

    Details

    - Participants will receive either 1) first CBD on day one followed by placebo within a two week follow-up period or 2) first placebo followed by CBD within a two week follow period. - Electrical brain activity will also be measured using a non-invasive technique called electroencephalography (EEG). - Final testing will be performed 3 hours after the intervention.

    Potential benefits

    Main benefits

    Pain

    Additional benefits

    Mental health

    Sensory function

    Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more

    • Trial recruitment status
    • Recruiting soon
    • Trial start date
    • 1 Jul 2024
    • Organisation
    • University of Miami
    • Trial recruitment status
    • Recruiting soon
    • Trial start date
    • 1 Jul 2024
    • Organisation
    • University of Miami

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more