Effects of CBD/CBD-A Oral Extract on Resting-state EEG and Neuropathic Pain Symptoms After SCI

Drug

Pain

Online since 28 August 2023, updated 569 days ago

About this trial

This trial is enrolling individuals with spinal cord injuries to test the effect of Cannabidiol (CBD) on pain severity. If included, participants will receive either: 1) CBD on day one followed by placebo within a two week follow-up period; or 2) placebo first followed by CBD. Researchers will measure the effect of CBD on pain symptoms, pain intensity, pain unpleasantness, and skin sensitivity to hot and cold temperature; they will also measure the effect of CBD on brain electrical activity using electroencephalography (EEG). Final testing will be performed 3 hours after each intervention.

Included participants

Gender

All

Age

18 - 64 years

Injury level

C1 - S5

Severity (AIS)?

AIS-A

AIS-B

AIS-C

AIS-D

Time since injury

All

Injury type

Traumatic

Healthy volunteers

C1-S5

Additionally, participants must

NOT have psychopathology

NOT have presence of significant medical illness

have had continuous neuropathic pain for three months

What’s involved

Type

Drug

Details

- Participants will receive either 1) first CBD on day one followed by placebo within a two week follow-up period or 2) first placebo followed by CBD within a two week follow period. - Electrical brain activity will also be measured using a non-invasive technique called electroencephalography (EEG). - Final testing will be performed 3 hours after the intervention.

Potential benefits

Main benefits

Pain

Additional benefits

Mental health and psychosocial factors

Sensory function

Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

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Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

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