Effect of Hypercapnia Treatment on Respiratory Recovery After Spinal Cord Injury

General health
Online since 15 August 2023, updated 188 days ago

About this trial

This trial is enrolling individuals with chronic spinal cord injuries to test the feasibility of daily acute intermittent hypercapnia (dAIHc) and its effect on respiratory function and sleep apnea. dAIHc is a technique to strengthen respiratory muscles. Sleep apnea (where your breathing stops and starts while breathing) can prevent your body from getting enough oxygen and may require an external device with pressurized air to keep your breathing steady. The investigators hypothesize that daily hypercapnia treatments (delivering higher than normal amounts of a gas called carbon dioxide) may improve respiratory function and sleep apnea. If included, participants will undergo either: 1) active dAIHc treatment; or 2) a sham intervention (pressurized air). Each arm includes 5 treatment days per week, for two weeks. Final testing will be performed at the end of the two week period.

Included participants

Gender
All
Age
18 - 89 years
Injury level
C1 - S5
  • Severity (AIS)?
  • AIS-A
    AIS-B
    AIS-C
    AIS-D
    Time since injury
    ≥ 6 months
    Healthy volunteers
    No
    C1-S5
    Additionally, participants must
    NOT have severe congestive heart failure.
    NOT have a stroke, myocardial infarction or recent surgery.
    NOT be receiving continuous mechanical ventilation

    What’s involved

    Type

    Observational

    Details

    - Participants will undergo either 1) active dAIHc or 2) a sham intervention 5 days per week, for two weeks - Final testing will be performed after 2 weeks

    Potential benefits

    Main benefits

    General health

    Additional benefits

    Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more

    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 1 Mar 2023
    • Organisation
    • VA Office of Research and Development
    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 1 Mar 2023
    • Organisation
    • VA Office of Research and Development

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more