Study to Evaluate the Safety and Pharmacokinetics of ALMB-0166 in Patients With Acute Spinal Cord Injury

Drug
General health
Online since 7 February 2023, updated 386 days ago

About this trial

This trial is enrolling individuals with acute (less than 72 hours), incomplete cervical and thoracic spinal cord injuries to test the safety, tolerability and overall activity in the body (pharmacokinetics) of an experimental drug (ALMB-0166). The drug is believed to reduce local inflammation and scar formation, thus improving nerve growth and recovery. If included, participants will either receive a single dose of: 1) the active drug; or 2) a placebo (inactive) drug. Outcomes will be followed for up to 2 months.

Included participants

Gender
All
Age
18 - 75 years
Injury level
C4 - T12
  • Severity (AIS)?
  • AIS-B
    AIS-C
    Time since injury
    ≤ 72 null
    Healthy volunteers
    No
    C4-T12
    Additionally, participants must
    be scheduled to undergo a spinal surgery within 72 hours after initial injury.

    What’s involved

    Type

    Drug

    Details

    Participants will either receive a single dose of 1) the active drug or 2) the placebo within 72 hours after injury.

    Potential benefits

    Main benefits

    General health

    Additional benefits

    Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more

    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 15 Apr 2022
    • Organisation
    • AlaMab Therapeutics (Shanghai) Inc.
    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 15 Apr 2022
    • Organisation
    • AlaMab Therapeutics (Shanghai) Inc.

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more