Can Brief Exposure to Hyperoxia Improve Function After Chronic Spinal Cord Injury?

Drug
Sensory function
Online since 21 September 2022, updated 574 days ago

About this trial

This trial is enrolling individuals at least 3 months post-injury at the C5 to T10 levels to test the effect of breathing an increased concentration of oxygen above that of normal room air (hyperoxia) on sensory and motor function. If included, participants will undergo 4 sessions of breathing either: 1) room air; or 2) 99% oxygen through a face mask for 2 minutes. Each session will take approximately 1.5-2 hours. Duration of involvement in the study is a minimum of 7 weeks.

Included participants

Gender
All
Age
18 - 65 years
Injury level
C5 - T10
  • Severity (AIS)?
  • AIS-A
    AIS-B
    AIS-C
    Time since injury
    ≥ 3 months
  • Injury type
  • Traumatic

    Healthy volunteers
    No
    C5-T10
    Additionally, participants must
    NOT have frequent uncontrolled autonomic dysreflexia
    NOT have a cardiac or cardiovascular disease

    What’s involved

    Type

    Drug

    Details

    - participants will undergo 4 sessions of breathing either 1) room air or 2) 99% oxygen through a face mask for 2 minutes. - each session will take approximately 1.5-2 hours and will involve testing of skin sensation and testing of leg reflexes in response to electrical stimulation of the foot. - a total duration of involvement in the study is a minimum of 7 weeks

    Potential benefits

    Main benefits

    Sensory function

    Additional benefits

    Standing/walking/mobility

    Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more

    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 11 Jul 2022
    • Organisation
    • University of Alberta
    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 11 Jul 2022
    • Organisation
    • University of Alberta

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more