Can Brief Exposure to Hyperoxia Improve Function After Chronic Spinal Cord Injury?

Drug

Sensory function

Online since 21 September 2022, updated 822 days ago

About this trial

This trial is enrolling individuals at least 3 months post-injury at the C5 to T10 levels to test the effect of breathing an increased concentration of oxygen above that of normal room air (hyperoxia) on sensory and motor function. If included, participants will undergo 4 sessions of breathing either: 1) room air; or 2) 99% oxygen through a face mask for 2 minutes. Each session will take approximately 1.5-2 hours. Duration of involvement in the study is a minimum of 7 weeks.

Included participants

Gender

All

Age

18 - 65 years

Injury level

C5 - T10

Severity (AIS)?

AIS-A

AIS-B

AIS-C

Time since injury

≥ 3 months

Injury type

Traumatic

Healthy volunteers

C5-T10

Additionally, participants must

NOT have frequent uncontrolled autonomic dysreflexia

NOT have a cardiac or cardiovascular disease

What’s involved

Type

Drug

Details

- participants will undergo 4 sessions of breathing either 1) room air or 2) 99% oxygen through a face mask for 2 minutes. - each session will take approximately 1.5-2 hours and will involve testing of skin sensation and testing of leg reflexes in response to electrical stimulation of the foot. - a total duration of involvement in the study is a minimum of 7 weeks

Potential benefits

Main benefits

Sensory function

Additional benefits

Standing/walking/mobility

Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

Wings for Life supports SCITrialsFinder

Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

Learn more

Back to results