"SCRIBBLE" Spinal Cord Injury Blood Biomarker Longitudinal Evaluation

Online since 13 March 2022, updated 757 days ago

About this trial

Prospective, single center study designed to assess blood biomarkers for classifying injury severity and predict neurologic recovery in traumatic spinal cord injured (SCI) patients. Study will also e...

Included participants

Gender
All
Age
≥ 19 years
Injury level
C1 - L1
  • Severity (AIS)?
  • AIS-B
    AIS-C
    AIS-D
    Time since injury
    ≤ 24 null
  • Injury type
  • Traumatic

    Healthy volunteers
    No
    C1-L1

    What’s involved

    Type

    Observational

    Details

    This single center study at Vancouver General Hospital (VGH) will enroll patients with acute traumatic cervical and thoracic SCI who will have blood samples obtained daily for the first week post-injury. They will then have follow-up neurologic assessments at 6 and 12 months post-injury. The specific aims of the study are to: Validate serum Glial Acidic Fibrillary Protein (GFAP) and Neurofilament Light Chain (NF-L) as biomarkers of acute SCI for classifying injury severity and predicting neurologic recovery. Establish the relationship between serum and plasma levels of GFAP and NFL Establish the accuracy of point of care devices for measuring GFAP in serum, plasma, and whole blood. Support biospecimen collection for the International Spinal Cord Injury Biobank (ISCIB)

    Potential benefits

    Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more

    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 17 Mar 2023
    • Organisation
    • University of British Columbia
    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 17 Mar 2023
    • Organisation
    • University of British Columbia

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more