Transcutaneous Stimulation in Spinal Cord Injury

Technology
General health
Online since 26 September 2022, updated 512 days ago

About this trial

This trial is enrolling individuals with chronic cervical (neck area) spinal cord injuries to test the effect of skin surface (transcutaneous) spinal cord stimulation (TSCS) on autonomic function, in particular on blood pressure management. The procedure stimulates the spinal cord using electrodes placed on the skin. If included, participants will complete 7-8 study visits, of between 3-5 hours. Researchers will provoke orthostatic (blood pressure) variation as the participant lies on an adjustable tilt table, measuring blood pressure either with or without stimulation. The study hopes to identify the optimal electrode placement and stimulation parameters to regulate blood pressure.

Included participants

Gender
All
Age
21 - 70 years
Injury level
C1 - T6
  • Severity (AIS)?
  • AIS-A
    AIS-B
    AIS-C
    Time since injury
    ≥ 1 year
  • Injury type
  • Traumatic

    Healthy volunteers
    No
    C1-T6
    Additionally, participants must
    NOT be ventilator dependent
    NOT have a history of diabetes

    What’s involved

    Type

    Technology

    Details

    - Participants will complete 7-8 study visits, of between 3-5 hours. - An orthostatic provocation will be performed where the participant is lying on a table that adjusts their body position from horizontal to vertical. - This tilt-table test will be performed either with or without transcutaneous spinal cord stimulation. - Final testing will be performed after 2 years.

    Potential benefits

    Main benefits

    General health

    Additional benefits

    Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more

    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 1 Apr 2022
    • Organisation
    • VA Office of Research and Development
    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 1 Apr 2022
    • Organisation
    • VA Office of Research and Development

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more