Operant Conditioning of Spinal Reflexes Training System--Reflex Operant Down Conditioning

Rehabilitation
Spasticity
Online since 3 April 2022, updated 694 days ago

About this trial

This is a clinical trial recruiting individuals with chronic incomplete spinal cord injuries to test the effect of an exercise training intervention on spasticity. Spasticity involves muscle stiffness or involuntary muscle contraction movements and is characterized by increased reflexes. The training targets the reduction of leg reflex strength by modifying nerve activity. If included in the study, participants will undergo assessment of reflex activity and a training intervention of 45 clinical visits over about six months. Final testing, including reflex activity, walking speed and distance, balance, functional independence, and quality of life will be performed after 3 months.

Included participants

Gender
All
Age
≥ 18 years
Injury level
C1 - T10
  • Severity (AIS)?
  • AIS-B
    AIS-C
    AIS-D
    Time since injury
    ≥ 1 year
  • Injury type
  • Traumatic

    Non-traumatic

    Healthy volunteers
    No
    C1-T10
    Additionally, participants must
    • ability to ambulate at least 10 m with or without an assistive device within 100 seconds
    • have clinical signs of spasticity in the plantarflexor muscles (gas pedal movement).
    • NOT have a pre-existing or confounding neurological condition (e.g., history of Multiple Sclerosis, Traumatic Brain Injury, Stroke, Parkinson's disease)

    What’s involved

    Type

    Rehabilitation

    Details

    - The study involves approximately 45 visits with a total study duration of about 6 months - The reflex activity of the leg affected by spasticity will be examined - A new training intervention will be performed

    Potential benefits

    Main benefits

    Spasticity

    Additional benefits

    General health

    Mental health

    Standing/walking/mobility

    Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more

    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 23 Aug 2023
    • Organisation
    • Medical University of South Carolina
    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 23 Aug 2023
    • Organisation
    • Medical University of South Carolina

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more