Improving Ventilatory Capacity in Those With Chronic High Level SCI

Drug
General health
Online since 3 April 2022, updated 835 days ago

About this trial

The purpose of this study is to find out if the drug Buspar increases breathing capacity in individuals with chronic, high-level spinal cord injuries. Buspar is already approved and in clinical use to treat anxiety disorders. In earlier studies, Buspar was shown to improve breathing function in disorders other than SCI. This study focuses on breathing function during exercise. If included in the study, participants will randomly be assigned to one of two study groups: either taking Buspar pills and performing exercises; or taking placebo pills and performing exercises. Final testing, including breathing function, will be performed after 14 days.

Included participants

Gender
All
Age
18 - 50 years
Injury level
C1 - T3
  • Severity (AIS)?
  • AIS-A
    AIS-B
    AIS-C
    Time since injury
    ≥ 24 months
  • Injury type
  • Traumatic

    Non-traumatic

    Healthy volunteers
    No
    C1-T3
    Additionally, participants must
    able to perform arm crank exercise
    NOT have a heart disease (cardiomyopathy)
    NOT have high blood pressure (>140/90 mmHg or you are taking high blood pressure medication)

    What’s involved

    Type

    Drug

    Details

    - Taking Buspirone (Buspar) or placebo pills orally for 14 days

    Potential benefits

    Main benefits

    General health

    Additional benefits

    Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more

    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 29 Nov 2020
    • Organisation
    • Spaulding Rehabilitation Hospital
    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 29 Nov 2020
    • Organisation
    • Spaulding Rehabilitation Hospital

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more