Epidural and Dorsal Root Stimulation in Humans With Spinal Cord Injury

About this trial

This trial is enrolling individuals with chronic spinal cord injuries to test the effect of combining two spinal cord stimulation methods on movement and other bodily functions. One technique, epidural stimulation, activates spinal cord nerve networks using implanted electrodes placed next to the spinal cord. The other method, dorsal root stimulation, uses a similar approach to activate spinal nerve roots close to the spinal cord. Electrodes are implanted using a needle inserted through the skin and are removed when the study is completed. The study will explore whether this combined stimulation modifies spinal cord function related to movement. If selected, participants will undergo surgery for the implantation of the electrodes, and then will receive 10 rehabilitative sessions. Researchers will measure nerve function (electrophysiology) and movement, including overground walking. The study includes questionnaires for participants to assess changes in bowel, bladder, sexual function, and spasticity. Final testing will occur after about 4 weeks.