Spasticity After Spinal Cord Injury

Rehabilitation
Spasticity
Online since 5 November 2021, updated 837 days ago

About this trial

This is a clinical trial enrolling individuals with incomplete spinal cord injuries to study spasticity. Spasticity is common in SCI, ranging from mild stiffness or tightening of muscles to uncontrollable muscle contractions. One of the goals of this study is to better understand the specific spinal cord nerve pathways responsible for spasticity. Transcranial magnetic stimulation and magnetic resonance imaging (MRI) will be used to measure activity of spinal cord nerves. Participants will undergo 2-3 study visits with muscle and nerve testing and MRI. These imaging studies will be associated with clinical measures of spasticity, combining exercise training with an acoustic (sound) startle stimulus on arm and leg function. The goal is to improve arm and leg muscle recovery by enhancing control over spinal cord nerve networks. Participants do not have to have spasticity to participate in this study.

Included participants

Gender
All
Age
18 - 75 years
Injury level
C1 - T12
  • Severity (AIS)?
  • AIS-B
    AIS-C
    AIS-D
    Time since injury
    1 year - 75 years
  • Injury type
  • Traumatic

    Healthy volunteers
    Yes
    C1-T12
    Additionally, participants must
    NOT have implanted device, e.g. pacemaker

    What’s involved

    Type

    Rehabilitation

    Details

    2-3 study visits within a time span of a month Participation in muscle testing (upper and lower limb), nerve testing and magnetic resonance imaging (MRI) Participation in exercise training (with or without sounds delivered through headphones)

    Potential benefits

    Main benefits

    Spasticity

    Additional benefits

    Arm/hand function

    General health

    Standing/walking/mobility

    Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more

    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 13 May 2020
    • Organisation
    • Shirley Ryan AbilityLab
    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 13 May 2020
    • Organisation
    • Shirley Ryan AbilityLab

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more