Intelligent Spine Interface, Clinical (ISI-C)

About this trial

This study is enrolling individuals with chronic spinal cord injuries to study an electrical stimulation device intended to improve voluntary leg function. The device (Intelligent Spine Interface-Commercial; ISI-C) is implanted around the injured spinal cord to transfer recorded nerve signals from above the spinal cord lesion to electrodes below the lesion. Researchers want to see if the ISI device affects voluntary leg movement. This study hopes to understand how nervous system signals travel within the spinal cord, and then to develop a device that can restore volitional control of lower limbs. The study will collect data on safety, leg function (strength, walking) and balance, over 8 months. If selected for the trial, participants will receive imaging studies (e.g. X-rays, etc.), surgery to implant the ISI device, and will receive physical rehabilitation.