Efficacy and Safety of hUC-MSCs and hUCB-MSCs in the Treatment of Chronic Spinal Cord Injury

About this trial

This trial is recruiting individuals with chronic spinal cord injuries to study whether implanted stem cells derived from human umbilical cord tissue or umbilical cord blood (hUC-MSCs or hUCB-MSCs) are safe using various forms of injection. The trial will also determine whether the stem cells change locomotor (walking) function and/or muscle tension. Participants will be randomly assigned to one of seven groups. One arm is a control group that receives a placebo injection; the other six arms vary the placement of stem cell injections (e.g., into the blood stream, into the injury area, etc.) All participants will also receive standard rehabilitative care. After 1, 3, 6, and 12 months, each participant will be evaluated in terms of safety and changes in function.