Effects of Paired Associative Nerve Stimulation on Spinal Cord Injury Subjects

Technology
Standing/walking/mobility
Online since 4 November 2021, updated 1127 days ago

About this trial

This clinical trial is enrolling individuals with chronic incomplete spinal cord injuries to study the combined effects of magnetic brain stimulation and electrical spinal stimulation. Participants will receive transcranial magnetic stimulation (TMS), a non-invasive technique which uses a magnetic field to stimulate the brain. At the same time, electrical stimulation (trans-spinal direct current stimulation - tsDCS) will be applied to the spinal cord using skin-surface electrodes attached to the trunk. Together this repetitive stimulation combination is called paired associative stimulation (PAS), which has been shown to increase muscle function by increasing nerve activity, and thereby muscle strength and voluntary function. Paired stimulation will be combined with cycling exercises. If selected for the trial, participants will be randomly assigned to one of five study groups: four groups will receive stimulation using different settings, while one group (control) will receive sham (inactive) stimuli. Motor function and strength will be measured.

Included participants

Gender
All
Age
20 - 65 years
Injury level
C1 - T9
  • Severity (AIS)?
  • AIS-A
    AIS-B
    AIS-C
    AIS-D
    Time since injury
    1 year - 65 years
  • Injury type
  • Traumatic

    Non-traumatic

    Healthy volunteers
    No
    C1-T9
    Additionally, participants must
    have normal joint range of motion
    NOT have implanted device, e.g. pacemaker

    What’s involved

    Type

    Technology

    Details

    One visit with transcranial magnetic stimulation (TMS), trans-spinal direct current stimulation (tsDCS) and leg cycling exercise Baseline and follow-up assessments before and after the intervention

    Potential benefits

    Main benefits

    Standing/walking/mobility

    Additional benefits

    General health

    Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more

    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 9 Dec 2019
    • Organisation
    • Taipei Medical University Hospital
    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 9 Dec 2019
    • Organisation
    • Taipei Medical University Hospital

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more