PAS in Subacute SCI

Technology
Arm/hand function
Online since 4 November 2021, updated 694 days ago

About this trial

This is a clinical trial to investigate the effect of magnetic stimulation combined with electrical stimulation on upper extremity function in individuals with recent cervical (neck area) spinal cord injuries. The magnetic stimulation (transcranial magnetic stimulation; TMS), is a non-invasive technique which uses a magnetic field to stimulate the brain. A magnetic coil held near the head increases activity of nerves of the brain and spinal cord when it is turned on. The electrical stimulation (peripheral nerve stimulation; PNS) uses an electric current to activate nerves in the arms and hands. Using TMS and PNS together is called paired associative stimulation (PAS). PAS has been shown to improve voluntary muscle function in the arms and hands. The focus of this study is the application of PAS in individuals with SCI in the subacute time frame (1-4 months after injury). If selected for the trial, participants will be randomly assigned to one of two study groups, receiving either the PAS stimulation paradigm, or sham (inactive) PNS.

Included participants

Gender
All
Age
18 - 75 years
Injury level
C1 - C8
  • Severity (AIS)?
  • AIS-A
    AIS-B
    AIS-C
    AIS-D
    Time since injury
    1 month - 4 months
  • Injury type
  • Traumatic

    Vertebrae fracture

    Non-traumatic

    Ischemia

    Stenosis

    Spondylosis

    Healthy volunteers
    No
    C1-C8
    Additionally, participants must
    be invited to enroll in the study
    have activity in hands/fingers
    be able to undergo MRI

    What’s involved

    Type

    Technology

    Details

    Electrical and magnetic stimulation paradigm several times a week, for 12 weeks Outcome assessments on hand muscle function and overall independence

    Potential benefits

    Main benefits

    Arm/hand function

    Additional benefits

    Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more

    • Trial recruitment status
    • By invitation
    • Trial start date
    • 10 Oct 2019
    • Organisation
    • Helsinki University Central Hospital
    • Trial recruitment status
    • By invitation
    • Trial start date
    • 10 Oct 2019
    • Organisation
    • Helsinki University Central Hospital

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more