Umbilical Cord Blood Cell (MC001) Transplant Into Injured Spinal Cord Followed by the Locomotor Training

About this trial

This trial is recruiting individuals with chronic, complete spinal cord injuries to assess the effect of transplanting a type of stem cell (cells that can turn into different cell types). This study uses cells from the umbilical cord (umbilical cord blood mononuclear stem cells; UCBMSC). The cells will be surgically transplanted into the spinal cord. After the transplant, the study also adds lithium carbonate (Li2CO3) taken by mouth for 6 weeks, followed by intensive stepping (locomotor) training for 3-6 months (up to 6 hours per day, 6 days per week). If included in the study, participants will be randomly assigned to one of the three study groups: walking training only; walking training + UCBMSC transplantation + placebo; or walking training + UCBMSC transplantation + lithium carbonate. All participants will receive 3-6 months of intensive locomotor training and will be assessed for walking ability, other activities of daily living, and overall sensory and motor function over 48 weeks.