Functional Scaffold Transplantation Combined With Epidural Electrical Stimulation for Spinal Cord Injury Repair

Surgery
Standing/walking/mobility
Online since 8 November 2021, updated 834 days ago

About this trial

This is a trial to test the effect of implanting a collagen scaffold (e.g. a man-made structure intended to support implanted cells or growth factors although the implantation of cells is not stated) in combination with a technique for stimulating the spinal cord with an implanted electrode placed next to the spinal cord (epidural spinal cord stimulation: ESCS) on recovery after spinal cord injury. If included, the participant will undergo surgery for implantation of the collagen scaffold and receive ESCS after the surgery. If the participant already has an implanted collagen scaffold, they will only receive ESCS. This trial contains arms for both acute (< 14 days) and chronic (>6 months) SCI.

Included participants

Gender
All
Age
18 - 60 years
Injury level
C5 - L1
  • Severity (AIS)?
  • AIS-A
    Time since injury
    ≤ 60 years
  • Injury type
  • Traumatic

    Healthy volunteers
    No
    C5-L1
    Additionally, participants must
    have had a spinal cord injury either within the last 14 days or for at least 6 months.
    have a neurological level of injury between C4- T12/L1.
    have an ASIA impairment scale (AIS) A: complete; no feeling or movement below the injury.

    What’s involved

    Type

    Surgery

    Details

    If included, the participant will undergo surgery for implantation of the collagen scaffold and receive ESCS after the surgery. If the participant already has an implanted collagen scaffold, they will only receive ESCS.

    Potential benefits

    Main benefits

    Standing/walking/mobility

    Additional benefits

    General health

    Sensory function

    Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more

    • Trial recruitment status
    • Unknown
    • Trial start date
    • 1 Aug 2019
    • Organisation
    • Chinese Academy of Sciences
    • Trial recruitment status
    • Unknown
    • Trial start date
    • 1 Aug 2019
    • Organisation
    • Chinese Academy of Sciences

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more