NISCI - Nogo Inhibition in Spinal Cord Injury

Drug
Arm/hand function
Online since 6 September 2022, updated 639 days ago

About this trial

This trial is enrolling individuals with acute cervical (neck area) spinal cord injuries to assess an experimental drug (NG-101). In earlier studies, NG-101 appeared to neutralize a molecule in the spinal cord that blocks nerve growth. The research team wants to see if the drug promotes nerve regeneration. If selected for the study, participants must begin the series of drug injections within 4 to 28 days following SCI. Each will be randomly assigned to one of two study groups: 1) receiving six injections of NG-101 over 30 days, or 2) receiving six injections of a placebo over 30 days. This study hopes to build on evidence from a smaller preliminary trial that demonstrated reasonable safety and tolerability of this drug.

Included participants

Gender
All
Age
18 - 70 years
Injury level
C1 - C8
  • Severity (AIS)?
  • AIS-A
    AIS-B
    AIS-C
    AIS-D
    Time since injury
    4 days - 28 days
  • Injury type
  • Traumatic

    Healthy volunteers
    No
    C1-C8
    Additionally, participants must
    NOT have penetrating injury, e.g. gunshot or knife wound

    What’s involved

    Type

    Drug

    Details

    - The participant will be randomly assigned to one of the two study groups: 1) Those receiving six injections of NG-101 over 30 days, or 2) those receiving six injections of a placebo over 30 days. - Over a period of 24 weeks: physical examinations, functional activity testing, testing of how nerves are functioning using nerve stimulation techniques, and measurements of drug concentrations in the spinal fluid obtained by spinal tap

    Potential benefits

    Main benefits

    Arm/hand function

    Additional benefits

    Bladder health/function

    General health

    Mental health and psychosocial factors

    Standing/walking/mobility

    Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more

    • Trial recruitment status
    • Ended
    • Trial start date
    • 15 May 2019
    • Organisation
    • University of Zurich
    • Trial recruitment status
    • Ended
    • Trial start date
    • 15 May 2019
    • Organisation
    • University of Zurich

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more