Spinal Cord Stimulation and Autonomic Response in People With SCI.

About this trial

This is a trial to test the effect of stimulating the spinal cord, either with an implanted electrode placed next to the spinal cord (epidural spinal cord stimulation: eSCS) or via surface stimulation (transcutaneous spinal cord stimulation: tSCS), on blood pressure when the participant sits upright from lying down (orthostatic hypotension) and bladder, bowel, and sexual function. Individuals with a spinal cord injury who have previously been implanted with an epidural stimulator will be invited to participate in 2 visits (one screening visit to determine eligibility and one eSCS + measurement visit). If participants with SCI who do not have an epidural stimulator are included, they will participate in either 4 study visits (1 screening visit and 3 times 1-hour tSCS + measurement visits) or 21 study visits (1 screening visit, 5 times 1-hour tSCS + measurement, and 15 tSCS only visits). All measurements will be done in a lying and an upright position.