Canadian-American Spinal Cord Perfusion Pressure and Biomarker Study

Drug
General health
Online since 8 November 2021, updated 1066 days ago

About this trial

This is a trial to study the fluid surrounding the brain and spinal cord (cerebrospinal fluid: CSF) of patients with an acute spinal cord injury. Spinal cord perfusion pressure (SCPP) is measured as the difference between the mean arterial pressure (MAP) and the pressure in the CSF (intrathecal pressure: ITP). The main goals of this trial are to: test the effect of keeping the SCPP at or above 65 mmHg with a combination of increasing MAP and decreasing CSF from around the spinal cord (the intervention) on neurological recovery after acute SCI and, if this intervention allows a reduction in the use of MAP increasing drugs (vasopressors). find chemical markers in the CSF and blood that may be connected to neurological recovery after SCI. If included in the trial, a thin tube will be inserted into the participant’s lower spine from where the CSF will be collected every 8 hours, 3 times per day, for 7 days. The tube will then be removed. The participant will have a neurological exam at days 1-7, and months 3, 6, and 12 after injury. There is no control group in this trial.

Included participants

Gender
All
Age
≥ 17 years
Injury level
C1 - T12
  • Severity (AIS)?
  • AIS-A
    AIS-B
    AIS-C
    Time since injury
    ≤ 24 hours
  • Injury type
  • Traumatic

    Healthy volunteers
    No
    C1-T12
    Additionally, participants must
    have had spinal cord injury within 24 hours.
    have a neurological level of injury between C0 and T12.
    have one have one of the following ASIA impairment scale (AIS):

    What’s involved

    Type

    Drug

    Details

    A thin tube will be inserted into the participant’s lower spine from where the CSF will be collected every 8 hours, 3 times per day, for 7 days. The tube will then be removed. Neurological examinations at days 1-7, and months 3, 6, and 12 after injury.

    Potential benefits

    Main benefits

    General health

    Additional benefits

    Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more

    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 31 Aug 2019
    • Organisation
    • University of British Columbia
    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 31 Aug 2019
    • Organisation
    • University of British Columbia

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more