Activity-Dependent Transspinal Stimulation in SCI

Technology
Standing/walking/mobility
Online since 16 April 2024, updated 91 days ago

About this trial

This is a trial to compare the effect of two training types: 1) step training on a treadmill while the body is supported in a harness (Body Weight Support: BWS) alone compared to 2) BWS-assisted step training in combination with another technique for stimulating the spinal cord via the skin surface to modulate spinal cord activity (transspinal stimulation). This study is designed to determine if transspinal stimulation at several frequencies combined with BWS-assisted step training will have more effect on physiological and clinical tests of neurological functioning including walking than BWS-assisted step training alone. If included in this trial, the participant will be randomly assigned to 20 step training sessions of 1) BWS assisted step training alone (control condition), 2) BWS assisted step training with low frequency transspinal stimulation, or 3) BWS assisted step training with high frequency transspinal stimulation. Before and after each session standardized clinical tests will be performed.

Included participants

Gender
All
Age
18 - 65 years
Injury level
C1 - T11
  • Severity (AIS)?
  • AIS-C
    AIS-D
    Time since injury
    6 months - 65 years
  • Injury type
  • Traumatic

    Healthy volunteers
    No
    C1-T11
    Additionally, participants must
    have had an injury for at least 6 months.
    have a neurological level of injury between C1-T11.
    have one of the following ASIA impairment scale (AIS):

    What’s involved

    Type

    Technology

    Details

    - 20 session of step training with 1) BWS assisted step training alone (control condition), 2) BWS assisted step training with low frequency transspinal stimulation, or 3) BWS assisted step training with high frequency transspinal stimulation. - Participants will be randomly assigned to one of the three intervention groups. Participants will be allowed to know their assigned group’s intervention protocol. - Standardized clinical tests will be performed before the intervention and after the 20 sessions are completed.

    Potential benefits

    Main benefits

    Standing/walking/mobility

    Additional benefits

    General health

    Sensory function

    Spasticity

    Mechanism of action

    Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more

    • Trial recruitment status
    • Ended
    • Trial start date
    • 1 Aug 2018
    • Organisation
    • City University of New York
    • Trial recruitment status
    • Ended
    • Trial start date
    • 1 Aug 2018
    • Organisation
    • City University of New York

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more