Intrathecal Transplantation of UC-MSC in Patients With Late Stage of Chronic Spinal Cord Injury

Biological/cell based
General health
Online since 8 November 2021, updated 956 days ago

About this trial

This is a phase 2 trial to test the safety and use of umbilical cord stem cells (allogeneic umbilical cord derived mesenchymal stem cells: UC-MSC) in a “late stage” of chronic spinal cord injury (>12 months post-injury). If included, the participant will receive an intrathecal injection of either 1) UC-MSC or 2) placebo (no UC-MSC), into the CSF (cerebrospinal fluid) around the spinal cord, once a month for 4 months.  The participant will be followed for 12 months.

Included participants

Gender
All
Age
18 - 65 years
Injury level
C1 - S5
  • Severity (AIS)?
  • AIS-A
    AIS-B
    AIS-C
    AIS-D
    Time since injury
    12 months - 65 years
  • Injury type
  • Traumatic

    Healthy volunteers
    No
    C1-S5
    Additionally, participants must
    have a traumatic spinal cord injury for at least 12 months.
    have one of the following ASIA impairment scale (AIS):
    AIS A: complete; no feeling or movement below the injury,

    What’s involved

    Type

    Biological/cell based

    Details

    If included, the participant will receive an intrathecal injection of either 1) UC-MSC or 2) placebo (no UC-MSC), into the CSF (cerebrospinal fluid) around the spinal cord, once a month for 4 months. The participant will be followed for 12 months.

    Potential benefits

    Main benefits

    General health

    Additional benefits

    Arm/hand function

    Bladder health/function

    Sensory function

    Standing/walking/mobility

    Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more

    • Trial recruitment status
    • Unknown
    • Trial start date
    • 1 Sep 2019
    • Organisation
    • Third Affiliated Hospital, Sun Yat-Sen University
    • Trial recruitment status
    • Unknown
    • Trial start date
    • 1 Sep 2019
    • Organisation
    • Third Affiliated Hospital, Sun Yat-Sen University

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more