Task-specific Epidural Stimulation Study

About this trial

This trial is recruiting individuals with chronic spinal cord injuries to test whether spinal cord stimulation improves recovery of blood pressure regulation, voluntary movement, and standing. Participants will have an electrical device (16-electrode epidural array) surgically implanted into the lower back over the spinal cord. Epidural spinal cord stimulation will be combined with a standing device (stand training). Participants will be randomly assigned to one of four groups: epidural stimulation for voluntary leg movement; epidural stimulation for voluntary leg movement combined with stand training; epidural stimulation for cardiovascular function; or epidural stimulation for cardiovascular function with stand training. The main goals are to measure the effect of the stimulation on cardiovascular (blood pressure) and voluntary motor function, and to compare leg movement training only with leg movement training plus stand training. Assessments will also include respiratory, bladder, bowel and sexual function. Quality of life and potential health care costs also will be assessed.