Adipose Stem Cells for Traumatic Spinal Cord Injury

Biological/cell based

General health

Online since 3 November 2021, updated 492 days ago

About this trial

This study is enrolling individuals with spinal cord injuries to test the safety and effect of an experimental stem cell therapy. The cells used are derived from the adipose (fat) tissue of each participant. A minor surgery will be performed to obtain fat from the stomach or thigh. The stem cells will be separated from the fat and allowed to multiply for 4-6 weeks. These stem cells (called adipose-derived mesenchymal stem cells) will be injected by needle into the spinal fluid at the lumbar (lower back area) spine. Besides safety, researchers will measure any sensory or motor improvements. Follow up will occur over a period of 96 weeks.

Included participants

Gender

All

Age

≥ 18 years

Injury level

C5 - T12

Severity (AIS)?

AIS-A

AIS-B

Time since injury

2 weeks - 1 year

Injury type

Traumatic

Healthy volunteers

C5-T12

What’s involved

Type

Biological/cell based

Details

Minor surgery to harvest the adipose tissue from a small incision in you abdomen or thigh. Injection surgery (lumbar puncture) to place the stem cells into the cerebrospinal fluid. Outcome assessments and follow-up up to 96 weeks.

Potential benefits

Main benefits

General health

Additional benefits

Arm/hand function

Mental health

Sensory function

Standing/walking/mobility

Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

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