Intermittent Hypoxia to Enhance Motor Function After Spinal Cord Injury

Drug
General health
Online since 10 July 2024, updated 5 days ago

About this trial

This trial is enrolling individuals with spinal cord injuries to test the effect of intermittent hypoxia on breathing, sitting, standing, and walking. Intermittent hypoxia briefly delivers exposures of low oxygen, alternated with exposures of normal oxygen. Recent studies have shown that this treatment can strengthen motor nerve function after SCI; beneficial effects have been demonstrated with walking, breathing and limb strength. If selected, participants will undergo a session of intermittent hypoxia and for comparison, a sham-session of normal oxygen on a different day. The procedures will be done in 15 brief (1-2 minute) exposures of low oxygen alternated with 15 brief exposures to normal oxygen. In the sham session, the air delivery will be normal oxygen air alternating with normal room air. At the time of the sessions, participants will not know whether they are receiving intermittent hypoxia or the sham alternative. Outcomes will be assessed after each of the two sessions, measuring performance of certain movement and breathing tasks

Included participants

Gender
All
Age
18 - 65 years
Injury level
C4 - T12
  • Severity (AIS)?
  • AIS-A
    AIS-B
    AIS-C
    AIS-D
    Time since injury
    ≥ 6 months
  • Injury type
  • Traumatic

    Non-traumatic

    Healthy volunteers
    No
    C4-T12
    Additionally, participants must
    have a spinal cord injury for at least 6 months.
    have a neurological level of injury between C4 and T12.
    be between 16 and 65 years of age.

    What’s involved

    Type

    Drug

    Details

    The participant will attend two visits at least 7 days apart, one session of intermittent hypoxia and one session of sham intermittent hypoxia. The order of the sessions will be randomly determined and the participant will not be aware of which treatment he is receiving. Before and after the breathing task, the participant will perform the outcome assessments.

    Potential benefits

    Main benefits

    General health

    Additional benefits

    Standing/walking/mobility

    Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more

    • Trial recruitment status
    • Ended
    • Trial start date
    • 10 Jul 2017
    • Organisation
    • University of Florida
    • Trial recruitment status
    • Ended
    • Trial start date
    • 10 Jul 2017
    • Organisation
    • University of Florida

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more